Impact of Cerebrovascular Risk Factors over Age of Onset of Dementia Due to Alzheimer's Disease in a Sample of Patients with Low Schooling from Sao Paulo, Brazil (P04.201)

Abstract

Objective: To establish the impact of cerebrovascular (CV) risk factors and schooling over age of onset of dementia due to Alzheimer9s disease (AD). Background Low schooling and CV risk have been implied as causative factors for AD; it is unknown whether CV risk may impact age of AD onset in populations with low average schooling. Design/Methods: Patients with late-onset AD were assessed for gender, schooling, estimated age of dementia onset, and CV risk factors (systemic hypertension, diabetes mellitus, hypercholesterolemia, alcoholism, smoking, physical inactivity, obesity and waist circumference). Cut-off for waist circumference was 102cm for men and 88cm for women. Physical activity should happen before age 60 years-old, be non-work related and of at least moderate intensity (>=3 METS), involving equivalents to walking or running at least 2 km per week for 5 years or 1 km per week for 10 years, or engaging in other physical activities for at least 1 hour per week for 5 years or 30 min per week for 10 years. Stepwise logistic regression was employed for statistical analysis, significance at ρ Results: Among all 129 included patients, 87 (67.4%) were female and 42 (32.6%) were male, 83 (64.3%) reported physical inactivity, 112 (86.8%) had hypertension, 35 (27.1%) had diabetes mellitus, and 90 (69.8%) had hypercholesterolemia, all under treatment; mean weight was 63.5±12.9kgf, mean height was 156.5±9.5cm, mean waist circumference was 95.1±12.3cm (range 64-126), and mean body mass index was 25.85±4.5kg/m2 (range 14.28-41.62); mean schooling was 4.4±3.7 years (range 0-15) and mean estimated age of AD dementia onset was 72.4±6.2 years (range 60-88). Obesity was the strongest risk factor for AD onset before 80 years-old (OR=1.178;95%CI 1.016-1.366;ρ=0.03). Schooling and all other CV risk factors were not statistically significant. Conclusions: Obesity seems to impact the age of AD onset in Brazil, regardless of its effects over metabolic disturbances or physical inactivity. Supported by: CAPES-FAPESP. Disclosure: Dr. De Oliveira has received personal compensation for activities with Gerson Lehrman Group as a consultant. Dr. De Oliveira has received research support from Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior. Dr. Bertolucci has received personal compensation for activities with Novartis, Janssen Pharmaceutica, and Pfizer Inc. Dr. Chen has nothing to disclose. Dr. Smith has nothing to disclose.