Impact of Caryolanemagnolol on Gait and Functional Mobility on Individuals with Huntington’s Disease

Ran Du

doi:10.4314/tjpr.v14i9.24

Abstract

Purpose: To highlight the impact of caryolanemagnolol on gait measures in forward walking, balance and mobility measures, as well as in hand and forearm function measures.Methods: Twenty patients with Huntington’s disease (HD) on stable doses of caryolanemagnolol were evaluated after medication and again following resumption of medication. The improvement in spatiotemporal gait parameters was measured by GAITRite, balance and/or mobility using Tinetti mobility test (TMT), five times sit-to-stand test (5TSST), and six-condition Romberg tests, as well as the function of the hand and forearm by finger tapping and Luria tests on Huntington's disease rating scale (UHDRS) motor scale.Results: The results demonstrated significant improvement in the unified UHDRS motor scores, Tinetti mobility test (TMT) total and balance subscale scores, and the five times sit-to-stand test when oncaryolanemagnolol compared to off-caryolanemagnolol. Spatiotemporal gait measures, the six condition Romberg test, and UHDRS hand and forearm function items remained unaffected on caryolanemagnolol treatment. Improved TMT and 5TSST performance when on drug indicates that caryolanemagnolol use may improve balance and functional mobility in individuals with HD.Conclusions: Caryolanemagnolol improves chorea and functional mobility by improving dynamic balance in individuals without any negative impact on motor function in walking and transfers.Keywords: Huntington's disease, Caryolanemagnolol, Gait measures, Choreic movements, Mobility tests

Highlights

One of the characteristic and dangerous symptoms associated with Huntington's disease (HD) is chorea
The results showed a significant improvement in mean UHDRS total motor scores
The results revealed that there was no significant effect of caryolanemagnolol on spatiotemporal parameters of gait (Table 2)

Summary

Introduction

One of the characteristic and dangerous symptoms associated with Huntington's disease (HD) is chorea. The high doses of neuroleptics like olanzapine and zotepine have shown a significant improvement in chorea as well as fine motor tasks, oral functions, and some gait measures [4,5]. In another study tetrabenazine was shown to improve both chorea and functional measures of balance and gait like, Berg balance scale and dynamic gait index [8].

Results

Conclusion