Impact of Camel's Milk on Aluminum Chloride (Alcl3) - Induced Toxicity in Rats

Abstract

The present study was carried out to evaluate the efficiency of camel's milk to ameliorate the toxicity of aluminum chloride AlCl3 on some hematological parameters; hepatic,renal functions andlipids profile; as well ashistopathological alterations of some organs. Forty rats (8 / group) were divided into 5 treatment groups:Group1: Normal rats (negative control); Group2: AlCl3induced toxicity rats (positive control); Group3: AlCl3induced toxicity rats fed with raw camel milk; Group4: AlCl3 induced toxicity rats fed with heat treated camel milk; andGroup5: AlCl3 induced toxicity rats fed with sweet acidophilus camel milk.Rats were treatedby 5ml camel’s milk 10 min before the administration of 1 ml AlCl3 (0.5 mg / kgbody weight); and had their respective doses daily for 30 successive days orally. AlCl3 oral administration resulted in a significant decrease in red blood cells count (RBC's), significant increase in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH); while hemoglobin (Hb), hematocrite (Hct), platelets(plt), reticulocytes (Ret), mean corpuscular hemoglobin concentration (MCHC) did not revealed significant changes; the obtained anemia was macrocytic normochromic. The lipids profile; hepatic and renal functions showed non significant changes between different groups; however, histopathological examination showed variable alterations of varying severity in some organs; besides their response to camel's milk administration. Camel’s milk administration in groups 3, 4, 5 alleviated the toxic effect of AlCl3 with variable degrees between different groups.