Impact of Body Mass Index on Implantation Rate in ICSI Cycles

Abstract

Background: obesity and overweight are recognized as a growing global health problem Worldwide, prevalence of overweight or obesity, defined as an adult body mass index (BMI) of 25 kg m² or greater. Patterns of overweight and obesity differ between countries, regions and by country income, with overweight or obesity more prevalent among men in developed countries and among women in developing countries. Aim of the Work: This study aimed to evaluate the impact of female increased body mass index (BMI) on implantation rate and clinical pregnancy in women undergoing ICSI cycle. Patients and Methods: this is a retrospective study conducted on a total of 400 cycles of assisted reproduction treatment has been evaluated from Orabi IVF Centre and Mit_Ghamr IVF Centre. Data recruited from patient files from January 2016 to July 2018 who did ICSI trial during this period. Patients who included in our study were sub divided into 2 groups according to BMI: 1 st group: normal weight with BMI between 18 and 24.9 kg/m2. (200 case), 2 nd group: overweight and obese women ≥ 25 kg/m2 (200 case). Results: we showed that overweight and obese infertile women had a higher basal serum FSH, LH and estradiol levels than normal weight women. In our study group the duration of infertility was progressively higher as BMI increased. The two groups were comparable regarding female age were not statistically different in both groups. The duration of infertility showed no significant difference between the two groups. As in group (1) it ranges from 10-17 years with median duration of 6 years, while in group (2) it ranges from 0.5-23 with a median duration of 5 years this result a significant difference with p-value (0.057).Conclusion: female overweight and obesity appeared to have deleterious effects on ovarian response to stimulation in women undergoing IVF and implantation rate. Moreover, female obesity compromised IVF outcome.