Abstract
The impact of binary inorganic salt zinc chloride (ZnCl2) on the micellization behavior of triblock pluronic copolymer, F108 was investigated by various spectroscopic methods in the presence of Coumarin-6 (C6) as a fluorescent probe. Ground and excited state photophysical properties revealed that the microenvironment around the C6 molecule changes in the presence of ZnCl2 compared to that in a salt-free solution. The addition of salt to the medium increases the hydrophobicity and microviscosity of the micelle core. Due to the presence of ZnCl2, the central PPO core experiences dehydration, reduces the interaction between water molecules and PEO groups, and enhances the hydrophobic interaction between C6 and hydrophobic PPO parts in the micelle with more solubility of C6. This study helps to develop the property of copolymers as drug carriers in various pharmaceutical applications and drug delivery systems.
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