Impact of Bhavana on Laghu Sutashekhara Rasa - A promisable formulation in Ardhavabhedaka (migraine)

Abstract

Aim: To evaluate the impact of Bhavana on Laghu Sutashekhara Rasa (LSR). Materials and Methods: The raw drugs are identified and authenticated, and powder microscopy was done in the Pharmacognosy Laboratory, Institute for Post Graduate Teaching and Research in Ayurveda (IPGT), Gujarat Ayurved University (GAU), Jamnagar, Gujarat, India. The study includes organoleptic evaluation and microscopic evaluation. Physico-chemical parameters and high-performance thin layer chromatography (HPTLC) studies carried out at pharmaceutics laboratory, IPGT and RA, GAU, Jamnagar, Gujarat, India. LSR was levigated with Swarasa of Nagavalli (Piper betle Linn.) to prepare Bhavita Laghu Sutashekhara Rasa (BLSR). Both the samples were subjected to accelerated stability by following standard guidelines. Results and Discussion: The pharmacognostical results of LSR showed oleoresin content of Sunthi, dark brown content of Gairika, etc. Contents of BLSR showed Trichome of betel leaves loaded by Gairika, stomata with epidermal cells of betel leaves, fragments of annular vessels of Sunthi, etc. Physico-chemical analysis of LSR revealed loss on drying 1.0376% w/w, water-soluble extract 1.32% w/w, etc. Physico-chemical analysis of BLSR revealed loss on drying 1.8793% w/w, water-soluble extract 4.5% w/w, etc. In HPTLC, almost all spots were merging in both samples showing common characters in both the wavelengths. Conclusion: Disturbed walls ruptured cellular particles of ingredients signify that Bhavana incorporates additional therapeutic attributes and also increases the potency of drug