Abstract

We aimed to assess the impact of atrioventricular compliance (Cn) on the clinical outcome, pulmonary hypertension (PH) and right ventricular (RV) function changes after successful percutaneous balloon mitral valvuloplasty (PBMV). Using Doppler echocardiography Cn was estimated from the equation that has been previously validated. Mitral valve area, tricuspid annular plane systolic excursion (TAPSE), pulmonary artery pressure (PAP) and degree of TR severity were evaluated before, immediately and every 6 months with a median duration of 32 months after successful PBMV in 150 consecutive patients. Compared to control subjects patients with MS had significant lower Cn (P < 0.0001). An immediate drop in PAP and significant improvement of RV function was observed after PBMV. Cn was correlated with the degree of PAPs, TAPSE (P < 0.0001). Patients with Cn < 3.75 mL/mmHg had higher incidence of adverse outcome (developing atrial fibrillation, worsening RV function, progressive left atrial dilation and redo intervention). Multivariate regression analysis showed that the Cn was the strongest independent predictor of PAPs and RV functional before and after successful PBMV (P < 0.0001). Cn < 3.75 mL/mmHg was the cut-of value for prediction of clinical events at follow-up. The change and follow-up in RV function and pulmonary hypertension after successful PBMV were significantly correlated with the degree of Cn. This suggests a significant role of Cn in patients with MS, providing a good insight for intervention and utilizing Cn as a non-invasive hemodynamic index for risk stratification and proper timing for intervention in patients with MS.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.