Impact of atrial fibrillation on stroke, heart failure, and mortality in diabetic patients with coronary artery disease.

Abstract

The objective of this study was to evaluate the risk of stroke, heart failure (HF) and mortality in diabetic patients with coronary artery disease (CAD) with a diagnosis of atrial fibrillation (AF). The study population was identified as the diabetic patients presented with CAD from 2000 to 2011 and the case group was those with a diagnosis of AF whereas the control group did not have AF. The cumulative incidence of stroke, heart failure and mortality was demonstrated by Kaplan-Meier curves and the difference between the two groups was estimated by log-rank test. The Cox proportional hazard model was used to calculate the risk of the factors to the event, and the results were expressed by hazard ratios (HRs) and 95% confidence intervals (95% CIs). After controlling for the covariates, the risk of stroke, heart failure and mortality was 1.63-fold higher (adjusted HR =1.63, 95% CI =1.37-1.94) , 2.75-fold higher (adjusted HR = 2.75, 95% CI =2.25-3.36), 1.72-fold higher (adjusted HR = 1.72, 95% CI = 1.43-2.07) in the AF cohort compared to the non-AF cohort. After adjusting for the confounding factors, increased risk of stroke, heart failure, and mortality by 1.63, 2.75, 1.72 times with a concomitant diagnosis of AF in diabetic CAD patients was observed in this study.