Abstract
The present study is aimed to evaluate the antioxidant and hepatoprotective properties of selected ethanolic fractions of Fissidens grandiflora in ethanol-induced oxidative stress in rats. Initially, ethanolic extract of F. grandiflora was fractionated using column chromatography. The preliminary antioxidant screening of these fractions identified two main bioactive fractions (F3 and F4), which were found to have significant radical scavenging and metal ion chelation properties compared with ascorbic acid. Based on the antioxidant profile, F3 and F4 were evaluated for hepatoprotective activity in ethanol-intoxicated rats. The Wistar rats were grouped (n = 6) and treated with F3 and F4 (100 and 200 mg/kg), ethanol (5 g/kg, 20%w/v) and silymarin (100 mg/kg) orally for 28 days. The outcomes of the study found that chronic administration of ethanol significantly (P < 0.0001) altered the liver parameters and oxidative stress markers (MDA, SOD, and CAT). The co-administration of F4 prominently ameliorated the oxidative stress induced by ethanol compared to F3. Histopathological studies further supported the significant protective action of F4. The present study demonstrates that the F. grandiflora possess significant antioxidant properties by augmenting the magnitude of the antioxidant enzymes SOD and CAT and further reducing MDA levels.
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