Impact of Angiotensin I Converting Enzyme Insertion/Deletion Polymorphisms on Dilated Cardiomyopathy and Hypertrophic Cardiomyopathy Risk

Jianmin Yang,Yun Zhang,Xiao Meng,Yunhan Zhao,Ying Wang,Cheng Zhang,Panpan Hao,Mei Dong,Katriina Aalto-Setala

doi:10.1371/journal.pone.0063309

Jianmin Yang, Yun Zhang + Show 7 more

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https://doi.org/10.1371/journal.pone.0063309

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Journal: PLoS ONE	Publication Date: May 14, 2013
Citations: 11	License type: CC BY 4.0

Affiliation: Qilu Hospital of Shandong University

Abstract

BackgroundGenetic factors in the pathogenesis of cardiomyopathies have received a lot attention during the past two decades. Angiotensin I converting enzyme (ACE) insertion/deletion (I/D) polymorphisms were found to be associated with cardiomyopathies. However, the previous results were inconsistent. The current meta-analysis aims to examine the association of ACE I/D polymorphisms and dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM).MethodsEight studies on DCM (1387 controls and 977 patients) and eight studies on HCM (1055 controls and 827 patients) were included in this meta-analysis.ResultsThe overall data showed no significant association between ACE I/D polymorphism and DCM risk. Further subgroup analysis by ethnicity also did not find a significantly increased risk for D allele carriers among East Asians and Europeans. However, the overall analysis suggested that the D allele carriers might be associated with increased risk of HCM (DD/ID vs. II: OR = 1.69, 95% CI 1.04–2.74, P = 0.03).ConclusionIn summary, the meta-analysis indicated that certain ACE I/D polymorphism might be associated with HCM but not DCM susceptibility. Given the limited sample sizes, further large multicenter case-control investigation is needed.

Highlights

Dilated cardiomyopathy (DCM), which is characterized by ventricular chamber enlargement and systolic dysfunction with normal left ventricular wall thickness, leads to progressive heart failure, arrhythmias, and sudden or heart failure related death
Several genes encoding the components of the renin-angiotensin-aldosterone system (RAAS) have been revealed to be associated with cardiovascular diseases, including hypertension, myocardial infarction, ischemic stroke, and cardiomyopathy. [3,4,5] As dilated cardiomyopathy (DCM) to be considered, the insertion/deletion polymorphism in the angiotensin I converting enzyme gene (ACE I/D) has been commonly reported. [6,7] the previous results were inconsistent
[11] Two studies investigated the effect of Angiotensin I converting enzyme (ACE) I/D polymorphisms on both DCM and hypertrophic cardiomyopathy (HCM). [9,12] eight studies on DCM (1387 controls and 977 patients, Table 1) and eight studies on HCM (1055 controls and 827 patients, Table 2) were included in this meta-analysis (Figure 1)

Summary

Introduction

Dilated cardiomyopathy (DCM), which is characterized by ventricular chamber enlargement and systolic dysfunction with normal left ventricular wall thickness, leads to progressive heart failure, arrhythmias, and sudden or heart failure related death. [3,4,5] As DCM to be considered, the insertion/deletion polymorphism in the angiotensin I converting enzyme gene (ACE I/D) has been commonly reported. No large-scale studies have assessed the association between ACE I/D polymorphisms and DCM or HCM. This lack of knowledge emphasizes the importance of the present metaanalysis. We performed this meta-analysis to clarify this inconsistency between ACE I/D polymorphisms and DCM or HCM. The current meta-analysis aims to examine the association of ACE I/D polymorphisms and dilated cardiomyopathy (DCM) or hypertrophic cardiomyopathy (HCM)

Methods

Results

Conclusion