Abstract
This study sought to assess clinical significance of angiographic peri-stent contrast staining (PSS) after sirolimus-eluting stent (SES) implantation in a large multicenter study with 5-year follow-up. The j-Cypher PSS substudy is a multicenter study including 5712 patients (7838 lesions) who underwent follow-up angiographic study within 12months after SES implantation. Late acquired PSS was observed in 184 patients (3.2%) or 194 lesions (2.5%). Independent risk factors of PSS were chronic total occlusion and left anterior descending artery lesion, while negative risk factors were in-stent restenosis, diabetes mellitus, ≥70years of age, and left circumflex coronary artery lesion. Cumulative incidence of definite very late stent thrombosis (VLST) at 4years after the index follow-up angiography in lesions with PSS was significantly higher than that in lesions without PSS (5.3 versus 0.7%, P<0.0001). Late target-lesion revascularization (TLR) was also more frequently observed in the PSS group (13 versus 6.9%, P=0.01), while late TLR for restenosis excluding those TLR procedures for VLST tended to be higher in the PSS group (9.9 versus 6.3%; P=0.15). PSS found in 2.5% of lesions within 12months after SES implantation was associated with higher risk for subsequent VLST.
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