Impact of aneurysm morphology on aneurysmal subarachnoid hemorrhage severity, cerebral infarction and functional outcome

Abstract

ObjectiveAneurysmal subarachnoid hemorrhage (aSAH) is associated with high morbidity. The objective was to evaluate, whether specific morphological aneurysm characteristics could serve as predictive values for aSAH severity, disease-related complications and clinical outcome. MethodsA total of 453 aSAH patients (mean age: 54.9 ± 13.8 years, mean aneurysm size: 7.5 ± 3.6 mm) treated at a single center were retrospectively included. A morphometric analysis was performed based on angiographic image sets, determining aneurysm location, aneurysm size, neck width, aneurysm size ratios, aneurysm morphology and vessel size. The following outcome measures were defined: World Federation of Neurosurgical Societies (WFNS) grade 4 and 5, Fisher grade 4, vasospasm, cerebral infarction and unfavorable functional outcome. ResultsRegarding morphology parameters, aneurysm neck width was an independent predictor for Fisher 4 hemorrhage (OR: 1.1, 95%CI: 1.0–1.3, p = 0.048), while dome width (OR: 0.92, 95%CI: 0.86–0.97, p = 0.005) and internal carotid artery location (OR: 2.1, 95%CI: 1.1–4.2, p = 0.028) predicted vasospasm. None of the analyzed morphological characteristics prognosticated functional outcome. Patient age (OR: 0.95, 95%CI: 0.93–0.96, p < 0.001), WFNS score (OR: 4.8, 95%CI: 2.9–8.0, p < 0.001), Fisher score (OR: 2.3, 95%CI: 1.4–3.7, p < 0.001) and cerebral infarction (OR: 4.5, 95%CI: 2.7–7.8, p < 0.001) were independently associated with unfavorable outcome. ConclusionsThe findings indicate a correlation between aneurysm morphology, Fisher grade and vasospasm. Further studies will be required to reveal an independent association of aneurysm morphology with cerebral infarction and functional outcome.