Abstract
Our previous research has indicated that androgen deficiency may be a critical etiologic factor in the pathogenesis of meibomian gland dysfunction, tear film instability and evaporative dry eye.1–3 We hypothesize that this may be due, at least in part, to significant alterations in the lipid profile of meibomian gland secretions.3 To test this hypothesis, we examined whether androgen deficiency, such as that occurring during aging in both sexes, complete androgen insensitivity syndrome (CAIS), the use of anti-androgen therapy and Sjogren’s syndrome (SS),4–7 is associated with significant changes in the fatty acid (FA) patterns of neutral and polar lipids in meibomian gland secretions. In addition, we determined whether lipid profiles could be used to separate individuals into clinically identifiable groups.
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