Impact of an Integrated Yoga Therapy Protocol on Insulin Resistance and Glycemic Control in Patients with Type 2 Diabetes Mellitus.

Manoharan Mangala Gowri,Ramanathan Meena,Ananda Balayogi Bhavanani,Abu Srinivasan,Jayanthi Rajendran

doi:10.5041/rmmj.10462

Abstract

ObjectiveDiabetes mellitus (DM), characterized by chronic hyperglycemia, is attributed to relative insulin deficiency or resistance, or both. Studies have shown that yoga can modulate parameters of insulin resistance. The present study explored the possible beneficial effects of integrated yoga therapy with reference to glycemic control and insulin resistance (IR) in individuals with diabetes maintained on standard oral medical care with yoga therapy, compared to those on standard oral medical care alone.MethodsIn this study, the subjects on yoga intervention comprised 35 type 2 diabetics, and an equal number of volunteers constituted the control group. Subjects ranged in age from 30 to 70 years, with hemoglobin A1c (HbA1c) test more than 7%, and were maintained on diabetic diet and oral hypoglycemic agents. Blood samples were drawn prior to and after 120 days of integrated yoga therapy intervention. Fasting blood glucose (FBG), post-prandial blood glucose (PPBG), HbA1c, insulin, and lipid profile were assessed in both the intervention and control groups.ResultsThe intervention group revealed significant improvements in body mass index (BMI) (0.7 kg/m2 median decrease; P=0.001), FBG (20 mg/dL median decrease; P<0.001), PPBG (33 mg/dL median decrease; P<0.001), HbA1c (0.4% median decrease; P<0.001), homeostatic model assessment for insulin resistance (HOMA-IR) (1.2 median decrease; P<0.001), cholesterol (13 mg/dL median decrease, P=0.006), triacylglycerol (22 mg/dL median decrease; P=0.027), low-density lipoprotein (6 mg/dL median decrease; P=0.004), and very-low-density lipoprotein levels (4 mg/dL median decrease; P=0.032). Increases in high-density lipoprotein after 120 days were not significant (6 mg/dL median increase; P=0.15). However, when compared to changes observed in patients in the control group, all these improvements proved to be significant.ConclusionAdministration of integrated yoga therapy to individuals with diabetes leads to a significant improvement in glycemic control, insulin resistance, and key biochemical parameters.

Highlights

IntroductionAs per 2019 estimates, 77 million individuals had diabetes in India
Diabetes mellitus (DM) is a leading cause of mortality worldwide
Fasting blood glucose (FBG), post-prandial blood glucose (PPBG), hemoglobin A1c (HbA1c), insulin, and lipid profile were assessed in both the intervention and control groups

Summary

Introduction

As per 2019 estimates, 77 million individuals had diabetes in India. A host of evidence-based trials has shown that yoga can pronouncedly attenuate fasting blood glucose and improve glycemic control, besides improving the lipid levels and quality of life in diabetic paients.[5,6,7,8,9,10,11,12] Mind–body practices essentially depend on the ability of the mind to enhance physical health (and vice versa). The practice of yoga as a viable non-invasive approach has been steadily rising, thanks to evidence-based reports.[13,14,15] It must be stressed that yoga is generally safe and simple to learn and could be practiced by individuals who are interested in yoga learning.[16,17,18,19] yoga paves the way for nodal strategies to combat stress, reduce anxiety, and enhance positive emotions.[20]

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