Abstract
Low first-dose peak serum concentrations of amikacin and gentamicin are reported in intensive care unit (ICU) patients.1
Highlights
Low first-dose peak serum concentrations of amikacin and gentamicin are reported in intensive care unit (ICU) patients
The present study aimed at assessing the impact of giving high doses of amikacin (30 mg/kg) or gentamicin (8 mg/kg) in ICU patients with severe sepsis
Guideline targets for serum concentrations were used with ≥60 and ≥30 mg/L for amikacin and gentamicin, respectively
Summary
The present study aimed at assessing the impact of giving high doses of amikacin (30 mg/kg) or gentamicin (8 mg/kg) in ICU patients with severe sepsis
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