Impact of Amphetamine and Captagon abuse on the liver and renal function

Abstract

Background. Addiction is a multifaceted brain disorder characterized by compulsive substance use despite harmful consequences. The physiological effects of drugs, such as amphetamines and captagon, on organ functions remain a significant concern, with varying impacts based on substance type and duration of use. Aim of study. This study aimed to investigate the impact of amphetamine and captagon abuse on liver and kidney functions. By comparing physiological parameters between individuals with substance abuse history and a control group, the study sought to elucidate the health implications of long-term drug use. Methods. The study involved 50 participants: 30 with a history of substance abuse and 20 healthy controls. It assessed liver and kidney functions using biochemical and ELISA tests to measure AST, ALT, ALP, Total Serum Bilirubin, Serum Albumin, Serum Creatinine, and Blood Urea. Results. The study revealed a significant difference between drug users and controls, with drug users exhibiting higher levels of urea and serum creatinine. Liver function tests showed increased GOT, GPT and ALP levels in drug users. Furthermore, total serum bilirubin was significantly higher in drug users, indi­cating liver impairment. Age-related analysis showed more severe renal and liver dysfunction in older drug users, with notable increases in urea and serum creatinine levels with age (p=0.001 and p=0.009, respectively). Conclusion. Both amphetamines and captagon pose a significant health risk to renal and liver functions. This underscores the need for awareness and interventions targeted at mitigating the health implications of substance abuse, highlighting the importance of continuous monitoring and treatment strategies for affected individuals.