Abstract
Objective Anemia inevitably affects the survival of cancer patients. In clinical practice, patients with anemia and decreased blood volume are treated by component blood transfusion. Through targeted blood transfusion therapy, the efficacy of blood transfusion treatment can be validly improved, which renders clinical benefits in reducing transfusion-induced adverse reactions (ARs). This research project mainly investigated the impact of allogeneic leukocyte-depleted red blood cell (LDRBC) transfusion on inflammatory response and coagulation status of patients with postoperative recurrence of colon cancer (CC). Methods A total of 80 patients with postoperative recurrence of CC admitted to Changzhou Second People's Hospital affiliated to Nanjing Medical University from September 2017 to December 2020 were selected as the study subjects. 36 patients with allogeneic suspended red blood cell (RBC) transfusion were used as the control group (CG), and 44 patients receiving allogeneic LDRBC transfusion served as the observation group (OG). The two groups were compared regarding alterations in pretransfusion and posttransfusion serum inflammatory factors, stress indicators and coagulation function, incidence of ARs, postoperative infection, and average incision healing time. Results After blood transfusion, serum tumor necrosis interleukin- (IL-) 6, IL-10, factor-α (TNF-α), and C-reactive protein (CRP) decreased in both cohorts, with lower parameters in CG (P < 0.05); the stress indexes, adrenocortical hormone (ACTH), adrenaline (AD), norepinephrine (NE), and cortisol (Cor) increased, especially in CG (P < 0.05); prothrombin time (PT), thrombin time (TT), and activated partial prothrombin time (APTT) in CG were lower than those in OG, and FIB was higher than that in OG with significant differences between two cohorts (all P < 0.05). The two groups had similar cases of lung infection and wound infection (P > 0.05), but the incision healing time was evidently shorter in OG as compared to CG (9.73 ± 1.86 vs 14.67 ± 2.39 d, P < 0.05). The total incidence of ARs was 16.7% in CG and 6.9% in OG, with no significant difference (P > 0.05). Conclusions In the blood transfusion treatment for patients with postoperative recurrence of CC, LDRBC transfusion renders significant clinical benefits, which can effectively improve the coagulation function of patients, reduce stress reaction, and shorten incision healing time without increasing ARs during treatment and postoperative infection rate, which is worth popularizing.
Highlights
Colon cancer (CC) is a relatively prevalent gastrointestinal malignancy [1]
Patients receiving transfusion of red blood cell (RBC) suspension were assigned into the control group (CG; n 36) and those treated with transfusion of leukocyte-depleted red blood cell (LDRBC) suspension served as the observation group (OG; n 44)
TNF-α, C-reactive protein (CRP), IL-6, and IL-10 decreased, and the reductions were more significant in CG (P < 0.05, Figure 1)
Summary
Due to the rise in the living standard of people, there have been great changes in the dietary structure, composition, and habits [2]. The consumption rate of high protein and animal fat is increasing, coupled with the decrease in physical exercise and excessive smoking and drinking of men, in particular, leading to the rising incidence of CC [3]. Surgical resection is a vital means to ensure a favorable prognosis of patients [4]. For CC patients, the radical resection rate is only 50%–60%, which gradually decreases with the age of patients, and the 5 year survival rate after simple resection is Evidence-Based Complementary and Alternative Medicine less than 30% [5, 6]. Patients with anemia and decreased blood volume will be treated by blood component transfusion
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