Abstract
Background: Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases. This study aimed to analyze the impact of coffee intake and alcohol consumption on advanced liver fibrosis (ALF) in HIV-HCV co-infected patients. Methods: ANRS CO13-HEPAVIH is a French, nationwide, multicenter cohort of HIV-HCV-co-infected patients. Sociodemographic, behavioral, and clinical data including alcohol and coffee consumption were prospectively collected using annual self-administered questionnaires during five years of follow-up. Mixed logistic regression models were performed, relating coffee intake and alcohol consumption to ALF. Results: 1019 patients were included. At the last available visit, 5.8% reported high-risk alcohol consumption, 27.4% reported high coffee intake and 14.5% had ALF. Compared with patients with low coffee intake and high-risk alcohol consumption, patients with low coffee intake and low-risk alcohol consumption had a lower risk of ALF (aOR (95% CI) 0.24 (0.12–0.50)). In addition, patients with high coffee intake had a lower risk of ALF than the reference group (0.14 (0.03–0.64) in high-risk alcohol drinkers and 0.11 (0.05–0.25) in low-risk alcohol drinkers). Conclusions: High coffee intake was associated with a low risk of liver fibrosis even in HIV-HCV co-infected patients with high-risk alcohol consumption.
Highlights
Coffee intake has been shown to modulate both the effect of ethanol on serum gamma-glutamyl transferase (GGT) activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases
High coffee intake and being hepatitis C virus (HCV) cured were significantly associated with lower odds of having advanced liver fibrosis (ALF)
CO13 HEPAVIH cohort, after controlling for age, CD4, HCV clearance, ARV treatment and body mass index (BMI), we found that there is an inverse relationship between alcohol intake and coffee consumption on the risk of ALF
Summary
Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases. This study aimed to analyze the impact of coffee intake and alcohol consumption on advanced liver fibrosis (ALF) in HIV-HCV co-infected patients. Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in alcohol consumers and the risk of alcoholic cirrhosis in patients with chronic diseases [18]. In the context of HIV-HCV co-infection, high coffee intake has been found to have important benefits in terms of better adherence to treatment, less perceived toxicity [19,20], reduced levels of liver enzymes and lower risk of insulin resistance [15,17]. Several meta-analyses have shown that coffee consumption is associated with a significant delay in the progression of liver fibrosis [21] and a reduced risk of HCC [22]
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