Impact of adipose-derived allogeneic mesenchymal stem cell transplantation on nociceptive reactions and gait parameters in rats with experimental peripheral neuropathy

Abstract

Peripheral neuropathy is associated with chronic debilitating pain and is difficult to treat. In this regard, the development of cell therapy of neuropathic pain using adipose-derived mesenchymal stem cells (MSCs) seems to be relevant.The work was devoted to study the impact of adipose-derived allogeneic MSC transplantation on nociceptive reactions in response to mechanical and thermal stimuli and gait parameters in rats with sciatic nerve injury.It is found that a single local injection of MSCs at a dose of 1·106 cells/kg eliminates axotomy-induced mechanical and thermal hyperalgesia on the 14th day after transplantation, contributes to the recovery of the sciatic functional index and the dynamic gait parameters on the 7th day after transplantation, and prevents the development of gait disturbances in the long-term period.