Impact of adaptative capabilities of the organism on the clinical course of localised periodontitis of traumatic etiology

Abstract

The development and severity of chronic periodon-titis are associated with weak systemic inflammation in the body. Aggravating factors are somatic diseases (dis-eases of cardiovascular, endocrine, urinary and other sys-tems) and metabolic disorders, age, as well as bad habits. Changes in blood biochemical parameters in localized periodontitis have been little studied. The course of peri-odontal tissue disease against the background of a slug-gish systemic inflammatory response and an inconspicu-ous general reaction of systems and organs is relevant for determining the possible reaction of the body in response to the disease. Objective: Identify factors that deter-mine the adaptive reserves of the body, and assessment of their influence on the course of localized periodonti-tis of traumatic etiology (LPTE). Material and methods: the study involved patients with localized periodontitis of traumatic etiology of mild and moderate severity (45-75 years), their adaptive response was determined on the basis of C-reactive protein level in the blood serum, clinical analysis and calculation of the entropy of the leu-kocyte blood count. Results: оne of the factors indirect-ly leading to the development of localized periodontitis of moderate severity is the aging of the organism. With moderate severity of localized periodontitis, a statistical-ly significant increase in the number of monocytes and stab neutrophils was recorded compared with mild LPTE. A tense reaction of adaptation was detected in patients with moderate LPTE (72.3%), while in patients with mild LPTE, adaptive reactions were normal (62.8%). The con-tent of C-reactive protein in the blood serum within the preclinical range (3-10 mg/l) contributed to an 1.74 times increase in the risk of developing moderately severe lo-calized periodontitis compared with the clinical group with a C-RP concentration below 3 mg/l. The study of the content of C-reactive protein in the blood of patients with LPTE can be used to assess the progression of the course of the disease, the appearance of possible complications and relapse in the near future. Conclusion: аn increase in the level of C-reactive protein in the blood serum and a change in the entropy of the leukocyte blood count in-dicate a violation of the main homeostatic parameters, as well as a decrease in the adaptive capabilities of the body. The determination of these indicators before treatment makes it possible to predict the course and outcome of localized periodontitis of traumatic etiology.