Abstract
Objective: The aim of the study is to assess the therapeutic efficacy of drugs used in acne vulgaris by measuring the severity of acne using the Global Acne Grading System score (GAGS) and Cardiff Acne Disability Index (CADI) questionnaire score pre and post-drug therapy. Methods: The present study was conducted in the Department of Dermatology after getting approval from the Institutional Ethics Committee (No MC/190/2007/Pt1/MAR-2019/PG/123) dated 10/04/2019. It was an observational study for a period of 1 y. 172 patients were enrolled in the study. Patients were divided into 4 grades depending on their clinical manifestation. The severity of acne vulgaris and the quality of life were measured using the GAGS scale and the CADI questionnaire, respectively at the first visit and at the follow-up visit in all the grades of acne vulgaris. A correlation was done between the GAGS and the CADI score at the follow-up visit in all grades of acne. Results: It was observed that the GAGS score and the CADI score was significantly improved at the F/U visit (p<0.05) as compared to baseline in all the 4 grades of acne. A correlation between GAGS score and QoL using CADI scale was done using Pearson Parametric Correlation Test. In none of the groups, the correlation was significant (p>0.05). Conclusion: We can conclude from our study that following treatment with drugs, the clinical severity of acne decreased and there was also a significant improvement in the quality of life of patients.
Highlights
Skin is the largest organ of the body
Individuals suffering from disorders like polycystic ovarian disease (PCOD), hyperandrogenism, hypercortisolism and precocious puberty are at increased risk for the development of acne
A total number of 172 patients presenting with acne vulgaris were included in the study
Summary
Skin is the largest organ of the body. Acne vulgaris is the most common skin disorder affecting more than 80% of teenagers. It is a chronic inflammatory disease of the pilosebaceous glands and is characterized by the formation of blackheads (open comedones), whiteheads (closed comedones), papules, pustules, nodules, cysts and scars [1]. Certain drugs such as steroids, anticonvulsants, OCP, endocrine disorders may cause acne. Mild cases of acne have been reported in some neonates because of stimulation of follicles by adrenal androgen [5]
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