Impact of a restrictive vs liberal transfusion strategy on anastomotic leakage and infectious complications after restorative surgery for rectal cancer.

Abstract

The aim of this study was to investigate the impact of a restrictive vs liberal transfusion strategy on anastomotic leakage and infectious complications after rectal cancer surgery. Patients undergoing restorative proctectomy for rectal cancer between January 2008 and December 2013 were divided into four groups according to the perioperative lowest haemoglobin (Hgb) level and transfusion status: group 1 with Hgb level ≥10g/dl; group 2 with Hgb level ≥7 and <10g/dl who did not receive transfusion; and group 3 with Hgb level ≥7 and <10g/dl and group 4 with Hgb level <7g/dl, both of which received a transfusion. Clinical characteristics, anastomotic leakage and infectious complications within 30days of surgery were compared. There were 398 patients (66% men) with a mean age of 59.3±11.9years. Groups 1, 2, 3 and 4 included 162 (40.7%), 163 (41.0%), 47 (11.8%) and 26 (6.5%) patients, respectively. Perioperative characteristics were significantly different among groups regarding neoadjuvant chemo/radiotherapy use, preoperative albumin and Hgb levels, operative approach and blood loss, tumour size and stage, surgical margin involvement and histological differentiation. The unadjusted rates of overall infectious complications were 17.2%, 27.6%, 36.2% and 50% in groups 1, 2, 3 and 4, respectively (P=0.001). In the multivariate analysis, compared to group 2, group 3 was associated with an increased likelihood of organ/space surgical site infections (SSIs) (OR 3.63, 95% CI 1.29-10.22, P=0.01) with no significant differences in terms of anastomotic leakage, overall SSIs or overall infectious complications. Blood transfusion of haemodynamically stable patients with Hgb level ≥7g/dl is associated with increased organ/space SSIs in rectal cancer surgery.