Impact of a novel inflammation-based prognostic system on patients undergoing surgery for hepatocellular carcinoma: A retrospective study of 398 Japanese patients.

Abstract

4111 Background: Few studies have investigated the Glasgow Prognostic Score (GPS) in patients with hepatocellular carcinoma (HCC). Methods: To compare the prognostic value of the GPS and Cancer of the Liver Italian Program (CLIP) score in patients undergoing surgery for HCC. Kaplan-Meier and uni- and multivariate analyses were performed to compare the GPS with the CLIP score. Results: Three hundred ninety-eight patients were evaluated retrospectively. Kaplan-Meier analysis and log rank test revealed that a higher GPS was associated with overall survival after surgical treatment of HCC (p < 0.001) as well as CLIP score (p < 0.001). In addition, GPS can classify not only patients with HCC (p < 0.001) but also such patients with lower CLIP score (p < 0.001) into three independent groups. Univariate analyses using clinico-laboratory factors selected GPS (odds ratio, 2.994; 95% CI, 1.372-6.534; p = 0.006) as one of the predictive factors associated with overall survival after surgical treatment of HCC, as well as the CLIP score (odds ratio, 2.075; 95% CI, 1.295-3.326; p = 0.002). Multivariate analysis using these two scoring system disclosed that both GPS (odds ratio, 2.500; 95% CI, 1.124-5.561; p = 0.025) and CLIP score (odds ratio, 1.886; 95% CI, 1.164- 3.056; p = 0.010) were associated with overall survival after surgical treatment of HCC. Conclusions: GPS is not only a simple and convenient system for preoperative classification of patients with HCC, but also an important predictor of overall survival after surgical treatment of HCC. No significant financial relationships to disclose.