Abstract
Rationale: Women with BRCA gene mutations have a high risk of developing breast cancer. The Mediterranean Diet (MedD) is associated with a reduced risk of various cancer entities, including breast cancer, proposedly due to high dietary intake of omega-3 (n-3) and n-9 fatty acids (FA), combined with low intake of n-6 FA. The LIBRE study, a randomized multicenter trial including 660 women, examines potential effects of lifestyle modifications, including a MedD, in women with high genetic cancer risk. Here we aim to determine biological parameters that conceivably reflect adherence to the MedD, such as red blood cell membrane (RBCM) FA.
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