Abstract
Background The deregulation of the energy balance by the malnutrition leads to the dysfunction of the neuro- The metabolic mechanisms but these homeostatic problems can be corrected by nutritional supplements. In this study, we investigated the effects of flaxseed on metabolism and anxiety- depressive-like disorders in high fructose-fed (23%) Wistar rat. Methods One-month-old female Wistar rats were divided into four groups of six rats: 1. Control: (30 g of standard food + 30 ml of tap water), 2. Control supplemented with flaxseed (27 g standard food + 7 g flaxseed + 30 ml tap water) 3. Fructose (30 g standard food + 23% fructose) 4. Fructose supplemented with flaxseed (23 g standard food + 7gflaxseed + 23% fructose), after two months of diet, the rats underwent a battery of tests to evaluate the affective behavior (Open Field, Elevated Plus Maze and Forced Swimming Test) and biochemical analyzes of glucose, cholesterol and triglycerides. Results High fructose diet inducesadverse metabolic effects (increases blood sugar, cholesterol, triglycerides) and behavioral ones (depression). Forflaxseed, it does not correct anxiety, but decreases depression-like and metabolic disorders. Conclusion Our results suggest that a high fructose diet induces metabolic and behavioral dysfunctions. Flaxseeds have improved these conditions.
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