Impact of a formulation design on resultant dispersions of self-microemulsifying lipid systems

Hasan Naser M Y

doi:10.7324/japs.2021.110311

Abstract

Impact of a formulation design on resultant dispersions of self-microemulsifying lipid systems

Highlights

There is growing interest in the field of self-emulsifying lipid-based systems (SELBS) as an approach to improve the bioavailability of poorly water-soluble drug (Kim et al, 2019; Kovvasue et al, 2019; Sonia et al, 2019; Xiong et al, 2019)
There are key factors within the lipid composition which affect characteristic profiles of aqueous dispersions of oil formulations. Among those factors are type of oil, whether it is long-chain triglycerides (LCTs) or medium-chain triglycerides (MCTs), the use of cosurfactant which aids in the mechanism of emulsification (Hasan, 2014), and the type of nonionic surfactant, whether it is hydrophilic (HLB>12) or hydrophobic (HLB
In comparison to LCTs, there is a consensus among researchers that MCTs (C8–C10) are emulsified using various nonionic surfactants producing fine microemulsion systems

Summary

Introduction

There is growing interest in the field of self-emulsifying lipid-based systems (SELBS) as an approach to improve the bioavailability of poorly water-soluble drug (Kim et al, 2019; Kovvasue et al, 2019; Sonia et al, 2019; Xiong et al, 2019). Despite the fact that SELBS suit the most biopharmaceutical classification system category II compounds, which have low solubility and high permeability, other drug categories including class I, III, or IV can benefit from reformulation in oil vehicles. A comparison was drawn between resultant dispersions of commercial Ibuprofen liquigel capsules which represent a hydrophilic cosolvent-based system and selfmicroemulsifying lipid formulation. This was in an attempt to withdraw the attention of the paradox of systems which may show apparent in vitro failure and yet have good bioavailability profiles

Methods

Results

Conclusion