Abstract
BackgroundThe efficacy of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer’s disease (AD) has not been investigated. Therefore, we systematically reviewed the effect of TSG on cognitive deficits in a rodent model of AD.MethodsWe identified eligible studies published from January 1980 to April 2015 by searching seven electronic databases. We assessed the study quality, evaluated the efficacy of TSG treatment, and performed a stratified meta-analysis and meta-regression analysis to assess the influence of study design on TSG efficacy.ResultsAmong a total of 381 publications, 18 fulfilled our inclusion criteria. The overall methodological quality of these studies was poor. The meta-analysis revealed a statistically significant benefit of TSG on acquisition memory (standardized mean difference [SMD] = −1.46 (95 % CI: −1.81 to −1.10, P < 0.0001) and retention memory (SMD =1.93 (95 % CI: 1.40 to 2.46, P < 0.0001) in experimental models of AD. The stratified analysis revealed a significantly higher effect size for both acquisition and retention memory in studies that used mixed sex models and a significantly higher effect size for acquisition memory in studies that used transgenic models.ConclusionsOur meta-analysis highlights a significantly better treatment effect in rodent AD models that received TSG that in those that did not. These findings indicate a potential therapeutic role of TSG in AD therapy. However, additional well-designed and detailed experimental studies are needed to evaluate the safety of TSG.
Highlights
The efficacy of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer’s disease (AD) has not been investigated
Systematic reviews of animal studies synthesize the available evidence in an unbiased manner to provide evidence for the potential translational value of effective therapeutic interventions in animal models to humans [17], contribute to models of clinically relevant problems, and facilitate decisions regarding the design and conduct of subsequent human clinical trials [18]
The following terms were included in the searches: “Alzheimer’s disease” and “tetrahydroxystilbene glucoside”
Summary
The efficacy of 2, 3, 5, 4′-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) treatment on cognitive decline in individuals with Alzheimer’s disease (AD) has not been investigated. The number of people affected by AD is increasing rapidly worldwide, and more than 35 million people currently have AD. World Alzheimer Report 2015 showed that the total estimated worldwide cost of dementia is $818 billion, and it will reach the trillion dollar mark by 2018 [3]. Memory dysfunction is generally the first symptom of AD, and it is generally the most severe cognitive impairment. Despite massive research effort to elucidate the causes and mechanisms underlying AD, including recent advances in our understanding of its molecular pathology, effective treatment remains elusive, and none of the existing drugs are able to halt its progression [7, 8]. There is a growing interest in new therapeutic strategies for the treatment of AD [9]
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