Impact factor analysis for improvement in lung function of patients with COPD treated with Salmeterol/ fluticasone

Abstract

Objective To investigated impact factor on improvement in lung function of patients with C（）Pl） treated with ICS＋LABA. Methods COPD patients in study group were administered 50/500 lag Salmeterol/fluticasone （1puff bid） for 6 months. Eosinophil in sputum induction, inflammatory mediators （11.-8）,lung function test and FeNO measurement were performed in all COPD patients before and post treatment. Impact factors on improvement in lung function of patients with COPD treated with 50/500 μg Salmeterol/fluticasone were analyzed by using single factor and non-conditional logistic regression analysis method. Results Improvement in lung function of patients with COPD treated .with 50/500 μg Salmeterol/flutieasone were （86±11） ml, and improvement of lung function in control group were （19±16） ml （P 〈0.05）. We investigate all impact factors （including eosinophils in induced sputum,IL-8,FeNO and lung functions） on improvement in lung function of patients with COPD. The improvement m FEVj was not correlated with IL-8 in induced sputum, baseline FeNO and baseline FEV1 , respectively. While eosinophils in induced sputum and decrease in FeNO after treatment 〈 10 bbp were closely related with the change in FEV1. The future logistic regression analysis showed percentage of vosinophils in induced sputum and decrease in FeNO after treatment 〉 10 ppb are the major factors on improvement in lung function of patients with COPD. Conclusions Our study show percentage ofeosinophils, in induced sputum and decrease in FENO after treatment 〉 10 ppb maybe important predictors of improvement in lung function of patients with COPD treated with ICS＋LABA. Key words: Corticosteroid Acllte exacerbations of chronic obstructive pulmonary disease Lung function