Abstract
Immunohistochemical level of IMP3-protein in patients with rectal cancer in clinical stage II (141), were correlated with sociodemographic, pathohistological and clinical indicators and duration of overall-survival and progression-free-survival. Vascular invasion was associated with IMP3-positive immunostaining (p < 0.001). Vascular invasion ratio in the group of poorly-differentiated-tumors was 21 times higher than in the group of well-differentiated-tumors. IMP3-positive patients lived 2.2 times shorter than negative (p < 0.001). Patients with well-differentiated-tumors lived 1.7 times longer than the subjects with poorly-differentiated-tumors (p < 0.001). Patients without vascular invasion lived 2.7 times longer than the subjects with vascular invasion (p < 0.001). The risk of mortality was 2.3 times higher for IMP3 positive patients (p = 0.027) and 10.4 higher for the patients with vascular invasion (p < 0.001). IMP3-negative participants had 2.3 times longer free interval without disease (p < 0.001). The free interval without disease was 3.6 times longer in the group without vascular invasion (p < 0.001). The risk of disease relapse in the IMP3 positive group was 5.3 times higher (p < 0.001) and with vascular invasion was 8 times longer (p < 0.001). The risk of disease relapse was 6.8 times higher in the group with vascular invasion (p < 0.001). Patients with rectal cancer and high IMP3-protein level will have a shorter overall survival relative to patients without or with low levels of IMP3. The analysis of IMP3 expression by immunohistochemistry pointed IMP3 as an independent prognostic factor of clinical stage II rectal cancer.
Highlights
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, ranked as third malignancy in men (746,000 new cases per year), and as second in women (614,000 new cancer cases per year)[1]
In this study, using the method of immunohistochemistry, we investigated the expression of IMP3 protein, which plays a key role in the transmission and stabilization of RNA, cell growth and migration during embryogenesis
IMP3 is an mRNA-binding protein that function in RNA localization, stabilization and trafficking[17]. This protein exhibits the properties of an oncofetal protein, and its expression correlates with the aggressive behaviour of many tumors with adverse survival
Summary
Colorectal cancer (CRC) is one of the most common malignant tumors worldwide, ranked as third malignancy in men (746,000 new cases per year), and as second in women (614,000 new cancer cases per year)[1]. Tumor invasiveness and its metastatic potential are the main determinants of outcomes of CRC, and factors involved in these processes are obvious candidates for new prognostic indicators[5]. Studies have shown that IMP3 expression is negative in healthy mature tissue and is positive in malignant neoplasms of the colon, kidney, bladder, pancreas, stomach, breast and lung, and is associated with an advanced clinical stage with distant metastases and shorter overall survival[7,8,9,10]. IMP3 expression was analyzed for the first time in tumor samples of a selected population with rectal cancer in clinical stage II
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