Abstract
Background: Few data are available regarding theeffectiveness of immune checkpoint inhibitors in advanced uppertract urothelial carcinoma (UTUC) patients. Methods: To provide a real-world experience with anti-PD-1/PD-L1-based therapy in UTUC patients, we involved an Italian network in a multicenter retrospective analysis. Results: A total of78 UTUC patients were enrolled. The median follow-up was 25.1months. The median progression-free survival (mPFS) was 2.2months (95% CI 1.8-2.6), and the median OS (mOS) was 6.0months (95% CI 3.6-8.4). The Sonpavde score (including performance status >0, hemoglobin <10g/dl, liver metastases, time from prior chemotherapy ≥3months) splitthe patients into three groups (0 vs 1 vs 2-4 factors), efficiently predicting the OS and PFS outcome at the multivariate analyses (p<0.0001). Conclusion: The prognosis of unselected UTUC patients isstill unsatisfactory. The Sonpavde score was validated for the first time in an UTUC population, as a useful tool for the treatment decision-making process.
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