Abstract
DNA vaccines have become relevant subject matter, and efforts for their development have been increasing due to their potential as technology platforms applicable for prophylactic and therapeutic approaches for infectious diseases and for cancer treatment, allergies, and autoimmune diseases. This review aimed to summarize current knowledge about the plasmid DNA vaccine carrying the mycobacterial hsp65 gene (DNAhsp65), which demonstrates immunomodulatory and immunoregulatory properties of both the innate and adaptive immune systems. The possible mechanisms associated with the modulation and regulatory role of DNAhsp65 in the control of various conditions is also discussed.
Highlights
Vaccine development dates back to the 1790s and Edward Jenner, the pioneer of the smallpox vaccine [1]
These results present an alternative therapy through the use of the DNAhsp65 vaccine only or associated with existing drugs due to its ability to modulate the pattern of immune response, which can reduce damage caused by fungal infections
The DNAhsp65 vaccine has been shown to be a potential weapon for intervention in different diseases and pathological conditions
Summary
Received: 07 September 2020 Accepted: 19 November 2020 Published: 15 December 2020. DNA vaccines have become relevant subject matter, and efforts for their development have been increasing due to their potential as technology platforms applicable for prophylactic and therapeutic approaches for infectious diseases and for cancer treatment, allergies, and autoimmune diseases. This review aimed to summarize current knowledge about the plasmid DNA vaccine carrying the mycobacterial hsp gene (DNAhsp65), which demonstrates immunomodulatory and immunoregulatory properties of both the innate and adaptive immune systems. The possible mechanisms associated with the modulation and regulatory role of DNAhsp in the control of various conditions is discussed
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