Abstract
The most common contemporary depiction of the immune response is an early innate response, mounted by myeloid cells, followed by a delayed adaptive lymphoid responses mounted by lymphocytes. This depiction is based on myriad compelling data sets and has made powerful predictions with biological and clinical relevance. Nonetheless, it seems incomplete. Thus, there are lymphocytes that respond very rapidly, commonly to self-encoded molecules over-expressed by dysregulated and/or transformed tissues and cells. The evidence for such “lymphoid stress-surveillance” by gamma delta T cells has been provided by animal models, and supports ongoing clinical investigations of the potential host-protective role of gamma delta T cells in cancer.
Highlights
The most common contemporary depiction of the immune response is an early innate response, mounted by myeloid cells, followed by a delayed adaptive lymphoid responses mounted by lymphocytes
There are lymphocytes that respond very rapidly, commonly to self-encoded molecules over-expressed by dysregulated and/or transformed tissues and cells. The evidence for such “lymphoid stress-surveillance” by gamma delta T cells has been provided by animal models, and supports ongoing clinical investigations of the potential host-protective role of gamma delta T cells in cancer
Patients and methods The phenotype and functional potentials of gamma delta T cells have been monitored in a spectrum of patients receiving zoledronate, while the activation of gamma delta T cells in situ was attempted in a small two arm trial carcinoma patients, using zoledronate with and without interleukin-2
Summary
The most common contemporary depiction of the immune response is an early innate response, mounted by myeloid cells, followed by a delayed adaptive lymphoid responses mounted by lymphocytes. This depiction is based on myriad compelling data sets and has made powerful predictions with biological and clinical relevance. There are lymphocytes that respond very rapidly, commonly to self-encoded molecules over-expressed by dysregulated and/or transformed tissues and cells. The evidence for such “lymphoid stress-surveillance” by gamma delta T cells has been provided by animal models, and supports ongoing clinical investigations of the potential host-protective role of gamma delta T cells in cancer. Aim To determine whether aminobisphosphonate treatments with and without cytokines activate gamma delta T cells in patients, and to determine whether any such activation is safe and/or efficacious
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