Abstract
GVHR was elicited in adult F 1 hybrids by iv injection of parental spleen cells. The F 1 hybrids were then immunized with θ-AKR antigen. Plaque-forming cells (PFC) producing antibodies lytic for AKR thymocytes were enumerated in spleens of experimental animals using the method of cytolysis in agar-gel. The number of PFC found in spleens of animals grafted with parental cells was significantly lower than the number in spleens of animals grafted with syngeneic cells. The degree of suppression of immune response to θ-AKR depended on: (1) the duration of GVHR at the time of immunization, (2) the parental strain and the number of parental cells grafted to evoke GVHR, and (3) the source of cells grafted. Thymus and bone marrow cells when grafted together showed a synergistic effect in suppression of the host's immune response. Immunosuppression of the response to θ-AKR seems to be a more sensitive indicator of GVHR in adult F 1 hybrids than splenomegaly, which is commonly used as a means of assessment of GVHR. The possible role of immunosuppression in the pathogenesis of GVHR is briefly discussed.
Published Version
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