Abstract
8-Gingerol is one of the principal components of ginger, which is widely used in China and elsewhere as a food, spice and herb. It shows immunosuppressive activity on the immune responses to ovalbumin (OVA) in mice. In the present study, we found that 8-gingerol suppressed lipopolysaccharide (LPS) and concanavalin A (ConA)-stimulated splenocyte proliferation in vitro. In vivo, 8-gingerol not only significantly suppressed Con A-, LPS- and OVA-induced splenocyte proliferation (P < 0.05) but also decreased the percentage of CD19+ B cells and CD3+ T cell (P < 0.05) at high doses (50, 100 mg/kg). Moreover, OVA-specific IgG, IgG1 and IgG2b levels in OVA-immunized mice were reduced by 8-gingerol at doses of 50, 100 mg/kg. These results suggest that 8-gingerol could suppress humoral and cellular immune responses in mice. The mechanism might be related to direct inhibition of sensitized T and B lymphocytes.
Highlights
Today, many diseases, such as systemic lupus erythematosus and rheumatoid arthritis, are attributed to autoimmune diseases
8-Gingerol did not affect the viability of splenocytes treated with concentrations ranging from 0 to
These results assured us that the effects of 8-gingerol on splenocytes were due to its immunosuppressive activity, and not to cell death
Summary
Many diseases, such as systemic lupus erythematosus and rheumatoid arthritis, are attributed to autoimmune diseases. In the clinic numerous immunosuppressive drugs such as cyclosporin A, FK506, rapamycin, cyclophosphamide or prednisone, have been adopted to use for organ transplantation and to treat some autoimmune diseases These drugs have a narrow therapeutic range [1]. It is very necessary to search for new, potential immunesuppressant with improved safety profiles In recent years, suppression of immune responses by medicinal plant products as a possible therapeutic measure has become a subject of scientific investigation. Several plant components such as triperine and triptolide [3], brazilin [4], sinomenine [5]. We investigated 8-gingerol for its in vitro and in vivo immunosuppressive activity on the cellular and humoral immune response against OVA in BALB/c mice
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