Abstract
The response of children with acute malaria to skin testing with 3 antigens, to sensitisation with dinitrochlorobenzene, and to immunisation with Salmonella typhi vaccine and tetanus toxoid has been determined and compared with the responses of healthy children and of children with other acute illnesses. Lymphocytes from some patients in each group have been cultured in vitro and their response to stimulation with phytohæmagglutinin determined. Children with acute malaria showed a diminished antibody response to the O antigen of S. typhi and to tetanus toxoid. Their antibody response to the H antigen of S. typhi and their cellular immune reponses were normal.
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