Abstract
The immunostimulatory property of a synthetic polyphosphoramidate based on stearyl tyrosine (PPST) is described. The immunostimulatory activity of this negatively charged polymer was investigatedin vitro through examining the effect on the mitogen-induced lymphocytes proliferation by a tetrazolium-based colormetric assay and also through studying the primary plaque-forming cells (IgM PFC) responses of Balb/c mice after the intraperitoneal (i.p.) injection of the polymer with sheep red blood cells (SRBC). PPST exhibits specific and high immunostimulatory activityin vitro by the stimulation on lipopolysaccharide(LPS)-induced murine B-cells proliferation, which is probably due to the interaction between the polymer with LPS-responding B lymphocytes. This polymer also makes a significant increase of single antibody producing cells. The result shows that the stimulation rate to IgM PFC response of Balb/c mice achieved 77.9% (p<0.01) when 160 mg/kg of PPST was injected 4 h before with SRBC.
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