Abstract
ABSTRACT In this study, the effect of Moringa oleifera extracts were investigated on an immunosuppressed model of cyclophosphamide-induced Swiss mice. M. oleifera seed and root extracts (2.0 g kg−1 body wt) were administered orally for 7 consecutive days; cyclophosphamide (CP) (200 mg kg−1 i.p.) was administered by IV on the 4th day. Results indicated that the extracts of the M. oleifera seeds and roots ameliorated the immunosuppressive effects of CP on delayed type hypersensitivity (DTH) response, leukocyte counts, relative organ weight, IgM concentration, serum TNF-α assay and micro-histological images. This study demonstrated in vivo the therapeutic effect of M. oleifera on the immune response in clinical application.
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