Abstract
We examined the effects of 2″- or 3″-monoglycosylated α-galactosylceramides (α-GalCers) and 2″,3″-diglycosylated α-GalCers on allogeneic MLR and the proliferation of murine spleen cells. It was found that their ceramide portions greatly affect their immunostimulatory activities, and that the 3″-hydroxyl group plays a more important role in the immunostimulatory effects of α-GalCer derivatives than the 2″-hydroxyl group.
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