Abstract
The detection of A,B,O blood group specificity on some CEA preparations was carried out with anti-A,B,H antisera coupled to sepharose 4B and ( 125I)-labelled antigens. This method was compared to classical FARR's method using ammonium sulfate precipitation of the antigen-antibody complex. In this last procedure, the introduction of adjuvants (excess of γ-globulin or saliva perchloric extract) limits its sensitivity. The use of immunosorbents which allows to eliminate these adjuvants, makes the results more reproducible and the sensitivity higher. Using this method, A blood group determinant was identified in two CEA preparations. Moreover, binding inhibition of labelled A blood group substance to anti-A antiserum by these CEA corroborated this result.
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