Abstract
Unseparated human T cells or isolated OKT4 + and OKT8 + subsets were stimulated in allogeneic MLR and subsequently tested for their capacity to suppress fresh autologous responding cells in a second MLR. Contrary to the bulk of evidence regarding the immunoregulation of B-cell function, both OKT4 + and OKT8 + cells could be activated to form suppressors of the MLR and were equally radioresistant. An early peak of blastogenesis was observed when OKT4 + suppressors were used, and this event was completely radiosensitive. When the fresh responding cells were also fractionated into OKT4 + and OKT8 + subsets, no preference for suppressibility of either subset could be demonstrated, indicating that OKT4 + suppressors were acting directly and not through an inductive mechanism requiring OKT8 + effectors. It is suggested that when alloantigenic responses are involved, the human T-cell subsets defined by these monoclonal antibodies may be more accurately defined by the class of MHC antigen to which they respond than by their effector function.
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