Abstract
BALB/c mice develop both nonhealing cutaneous lesions and fatal systemic disease following subcutaneous (sc) inoculation of the protozoan parasite, Leishmania major. Several interesting features characterize this fulminant infection, and set BALB/c mice apart from other susceptible strains: (1) fatal disease in the BALB/c is virtually independent of infective parasite dose (Howard, Hale & Chan-Liew 1980), (2) a macrophage defect(s) appears to underlie the innate susceptibility of BALB/c mice to this strain of Leishmania (Behin, Mauel & Sordat 1979; Handman, Ceredig & Mitchell 1979; Nacy, Fortier, Pappas & Henry 1983; Mitchell, Anders, Brown, Handman, Roberts-Thomson, Chapman, Forsyth, Kahl & Cruise 1982) and (3) immunosuppression attributed to either lymphocytes (Howard, Hale & Liew 1980) or macrophages (Scott & Farrell 1981) develops in the later stages of infection, possibly the net result of vigorous parasite proliferation in defective macrophages.
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