Abstract
Background: Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological, biological, and clinical characteristics that have increased in incidence and prevalence in the last few decades. This study is aimed to find out the incidence of neuroendocrine tumors among the gastrointestinal tumors and to grade gastrointestinal neuroendocrine tumors.
 Materials and Methods: A total of 119 cases of gastrointestinal tumors of gastrointestinal neuroendocrine was included in the study. The paraffin blocks were retrieved and slides were stained with routine Hematoxylin and Eosin, synaptophysin, chromogranin, and Ki67. The histologic grading was done based on mitosis and Ki-67 index as per WHO 2017 classification.
 Results: Out of 119 cases of Gastrointestinal Tract tumor, 13 (10.92%) constituted neuroendocrine tumors. Duodenum was the most common site (38%) followed by the appendix (23%). The majority (1.9%) of the cases were categorized as of grade 1 followed by 2.3% of grade 2 and 1.19% of grade 3. Immunohistochemically, chromogranin, and synaptophysin were strongly expressed in all ten cases of neuroendocrine tumors. The Ki67 labeling index was <3 % in 10 cases, while it was in the range of 3 – 20 % in 2 cases and >20 % in one case.
 Conclusions: The incidence of gastrointestinal neuroendocrine tumors is on the rise. They should be considered in developing a differential diagnosis. Hence use of diagnostic modalities such as immunohistochemistry should be implemented for better treatment.
Highlights
Neuroendocrine tumors (NETs) are heterogeneous, slowgrowing tumors that arise from neuroendocrine cells present throughout the body.[1]
We have studied the trends of gastrointestinal neuroendocrine tumors among all gastrointestinal (GI) tumors received over 3 years along with IHC and compared the findings with existing Indian studies
The total number of GI tumors identified between 2018 and 2020 was 119 out of which 13 cases were neuroendocrine tumors that are comprised of 10.92 %
Summary
Neuroendocrine tumors (NETs) are heterogeneous, slowgrowing tumors that arise from neuroendocrine cells present throughout the body.[1]. The annual incidence of small intestinal NET. Among the gastrointestinal NET, the small intestine NET is most common.[4,5] Based on the Surveillance Epidemiology and End Results (SEER) Program registries, the incidence of neuroendocrine tumors of gastrointestinal tumors in Asians is 3.19 per 100,000.6. Gastrointestinal neuroendocrine tumors are rare slow-growing tumors with distinct histological, biological, and clinical characteristics that have increased in incidence and prevalence in the last few decades. This study is aimed to find out the incidence of neuroendocrine tumors among the gastrointestinal tumors and to grade gastrointestinal neuroendocrine tumors
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
