IMMUNOPHENOTYPIC PROFILE OF T ACUTE LYMPHOBLASTIC LEUKAEMIA IN A TERTIARY CARE CENTRE - OUR EXPERIENCE

Sumayya Shah,Saleem Hussain Mir

doi:10.21474/ijar01/12089

Abstract

Background:Studying the immunophenotypic profile of T-ALL patients in Kashmir and correlation of various demographic factors. Methods: 36 patients of all age groups were registered for this study of which 35 were included in the analyses. Result: 82.86% were males and 17.14% were females. 51.43% had common thymocyte T-ALL, 28.57% had pro T-ALL and 20% had mature thymocyte T-ALL. The average age at presentation was 18.60 years. 51.43% were CD1a positive. CD2 was positive in 70.83%. 88.57% were CD5 positive while 100% were positive for CD7. 42.86% were CD34 positive. The average bone marrow blast percentage was 82.43%. The average peripheral blood TLC was 92.73 x 103 cells/cumm. Conclusion: This is the first study to report immunophenotypic and demographic profile of T-ALL in Kashmir with the aim to increase understanding of the disease and contributing to more suitable treatment options.

Highlights

Studying the immunophenotypic profile of T-Acute Lymphoblastic Leukaemia (ALL) patients in Kashmir and correlation of various demographic factors
We sought to study and classify the immunophenotype characteristics of Kashmiri patients diagnosed with T-ALL and to correlate the results with age and gender as well as biological factors to understand the characteristics of the disease in Kashmiri patients
Of the remaining 6 females, 4 (11.43%) were diagnosed with pro T-ALL phenotype, 1 (2.86%) with common thymocyte T-ALL and 1 (2.86%) was diagnosed with mature thymocyte T-ALL phenotype

Summary

Result

82.86% were males and 17.14% were females. 51.43% had common thymocyte T-ALL, 28.57% had pro T-ALL and 20% had mature thymocyte T-ALL. 82.86% were males and 17.14% were females. 51.43% had common thymocyte T-ALL, 28.57% had pro T-ALL and 20% had mature thymocyte T-ALL. The average age at presentation was 18.60 years. The average bone marrow blast percentage was 82.43%. The average peripheral blood TLC was 92.73 x 103 cells/cumm

Conclusion

Findings

CD Markers pro T ALL common thymocyte T mature thymocyte T