Abstract
We have previously demonstrated by the indirect immunofluorescence test that sera of some patients with malignant melanoma contain antibodies to antigens associated with nucleoli of their own and homologous melanoma cells. These studies have shown a correlation between the presence of nucleolar antigen in tumor cells of a melanoma patient, progressive tumor growth, and poor prognosis. The present study was undertaken to determine if nucleoli of melanoma cells possess any unusual morphological features and to demonstrate the nucleolar antigen at the light and electron microscope level by the immunoperoxidase reaction.Melanoma cells from selected patients were examined by electron microscopy after growth in tissue culture.
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