Abstract
This compact monograph, sixth of an internationally edited series on endocrinology, reports several years' research on the antigenicity of insulin. Its greatest value is the application of new immunochemical methods to clinical material, yielding information important in dealing with insulin-treated diabetics. The ultimate contribution to allergic patients (one third of the total) would be the administration of synthetic human or purified animal insulin. True insulin resistance appears in only 0.1% of this group. The author reviews the mechanisms of cellular and humoral response to insulin antigen. Details of immune testing techniques, such as immunofluorescence, lymphocyte transformation test, antigen binding by leukocytes, and the immune adherence method, are thoroughly presented. Applied to 14 patients treated in the diabetic clinic in Frankfurt, Germany, and correlated with skin biopsy, they permit interpretation of therapy of the particular allergy. Injection of guinea pigs with bovine insulin failed to induce immunological lesions in pancreas or
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