Abstract
Mesenchymal stem cells (MSCs) are prototypical adult stem cells, identified as an adherent, fibroblast-like population positive for CD105, CD90 and CD73, and lacking hematopietic markers. MSCs can be isolated from different adult tissues including bone marrow (BM), umbilical cord, skeletal muscle and adipose tissue. MSCs have a potent immunomodulatory function via soluble factors, including PGE2, TGF-β, indoleamine 2,3-dioxygenase (IDO), IL-10, and HGF. Treatment with MSCs can improve type 1 diabetes, liver fibrosis and arthritis via their immunomodulatory function. Intra-bone marrow bone marrow transplantation (IBM-BMT) can replace not only hemopoietic stem cells (HSCs) but also MSCs. IBM-BMT seems to be the best strategy for allogeneic BMT, and may improve aging-related diseases, including type 2 diabetes and osteoporosis. IBM-BMT has also been shown to be the most effective strategy to prevent the rejection of organ allografts. This review summarizes the immunomodulatory properties and therapeutic application of bone marrow derived-MSCs.
Highlights
Mesenchymal stem cells (MSCs) are multi-potent progenitor cells isolated from bone marrow (BM) [1] and other adult tissue including skeletal muscle [2], adipose tissue [3], umbilical cord [4], synovium [5], the circulatory system [6], dental pulp [7], amniotic fluid [8], fetal blood [9] and lung [10]
One report has suggested that allogeneic bone marrow-derived MSCs (BMMSCs) inhibit the activation, proliferation and IgG secretion of B cells in a BXSB mouse model of human systemic lupus erythematosus [61]
We previously reported that the transplantation of BMMSCs via Intra-bone marrowbone marrow transplantation (IBM-BMT) in conjunction with the induction of HO-1 could eradicate type 2 diabetes
Summary
Mesenchymal stem cells (MSCs) are multi-potent progenitor cells isolated from bone marrow (BM) [1] and other adult tissue including skeletal muscle [2], adipose tissue [3], umbilical cord [4], synovium [5], the circulatory system [6], dental pulp [7], amniotic fluid [8], fetal blood [9] and lung [10]. There have been reports indicating that MSCs secrete a variety of factors that promote tissue repair, stimulate proliferation and differentiation of endogenous tissue progenitors, and decrease inflammatory and immune reactions [24,25,26]. MSCs have been shown to modulate immunological responses via T-cell suppression [24,26,27,28].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
