Abstract
Abstract This study aimed to investigate the immunomodulatory effects of walnut (Juglans regia L.) oligopeptides (WOPs). Female BALB/c mice were randomly assigned to control, whey protein control and three WOPs groups, given deionized water, 220 mg/kg BW whey protein, 110, 220 and 440 mg/kg BW WOPs daily through drinking water for 30 days, respectively. The immonomodulatory activity determination of WOPs involved innate and adaptive immunity, spleen T lymphocyte subpopulations, serum cytokine and immunoglobulin levels. Our results showed that WOPs could significantly improve humoral and cell-mediated immune responses, macrophage phagocytosis and natural killer cell activity. Moreover, increased T and Th cells percentages, cytokines secretion of interleukin (IL)-2, IL-10, IL-12 and granulocyte–macrophage colony stimulating factor, and production of immunoglobulin (Ig)A, IgG, IgM and intestinally secreted IgA also contributed to these improvements. All these above indicated that WOPs could be a promising immunomodulatory dietary supplement at dosages ranging from 110 to 440 mg/kg BW.
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