Abstract
The immune balance controlled by T helper 1 (Th1) and T helper 2 (Th2) is crucial for immunoregulation and its imbalance causes various immune diseases including allergic disorders and asthma. It has been recently proposed that asthma may result from an imbalance between T helper 1 (Th1) and T helper type 2 (Th2) cells. Juglans sinensis Dode (family, Juglandaceae), Psoralea corylifolia Linn. (family, Fabaceae), and Cheong-a-hwan (herbal prescription composed of J. sinensis, P. corylifolia), which has been used widely in Korean traditional medicine, has been shown to exhibit various biological activities but its immunoregulatory activities have not been well studied. We investigated these activities of J. sinensis, P. corylifolia and Cheong-a-hwan on Th1/Th2 cytokine production using an ovalbumin-induced asthma animal model. Our results have shown that J. sinensis, P. corylifolia and Cheong-a-hwan and CsA have profound inhibitory effects on the accumulation of eosinophills into airways and blood. Also, they upregulated the production of OVA-specific Th1 cytokine (IFN-γ) and downregulated OVA-specific Th2 cytokine (IL-4) in culture supernatant of spleen cells. These results indicate that J. sinensis, P. corylifolia and Cheong-a-hwan extracts may be a potential novel therapeutic agent for asthma by modulating the relationship between Th1/Th2 cytokine balance.
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