Abstract
Immulina®, a high-molecular-weight polysaccharide extract from the cyanobacterium Arthrospira platensis (Spirulina) is a potent activator of innate immune cells. On the other hand, it is well documented that Spirulina exerts anti-inflammatory effects and showed promising effects with respect to the relief of allergic rhinitis symptoms. Taking into account these findings, we decided to elucidate whether Immulina®, and immunLoges® (a commercial available multicomponent nutraceutical with Immulina® as a main ingredient) beyond immune-enhancing effects, might also exert inhibitory effects in the induced allergic inflammatory response and on histamine release from RBL-2H3 mast cells. Our findings show that Immulina® and immunLoges® inhibited the IgE-antigen complex-induced production of TNF-α, IL-4, leukotrienes and histamine. The compound 48/80 stimulated histamine release in RBL-2H3 cells was also inhibited. Taken together, our results showed that Immulina® and immunLoges® exhibit anti-inflammatory properties and inhibited the release of histamine from mast cells.
Highlights
Arthrospira platensis (Spirulina) is a microscopic and filamentous cyanobacterium
Previous reports showed that Immulina® is a potent immune cell activator and activates NF-ĸB
Macrophages have been as immune cells, and their main categories: host defense, wound healing, and immune regulation
Summary
Arthrospira platensis (Spirulina) is a microscopic and filamentous cyanobacterium. It has a long tradition of use as food and has been used by humans for many years as food supplement in the form of health drinks, pills, or tablets. Spirulina became famous after it was used by NASA as a dietary supplement for astronauts. The safety of Spirulina has been well established. Administration (FDA) has categorized Arthrospira products “Generally Recognized as Safe” (GRAS). Spirulina has high nutritional values due to its high content in proteins (up to 70%), essential amino acids, minerals, essential fatty acids, vitamins, and antioxidants [1].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
