Immunomodulatory Activity ofMoringa oleiferain Albino Rats

Abstract

The study was conducted to evaluate immunomodulatory property of hot aqueous and ethanolic extracts of Moringa oleifera in albino rats. This study comprised of six groups containing six rats in each group. Group I served as control, received standard feed and water. Group II and IV received hot aqueous extract of Moringa oleifera @ 400 mg/kg b.wt, orally for 45 days. Group III and V received ethanolic extract of Moringa oleifera @ 400 mg/kg b.wt, orally for 45 days. Group VI received standard immunomodulatory drug Levamisole @ 50 mg/kg b.wt, orally for 45 days. A significant increase (P< 0.05) in HA titre was observed in levamisole treated group VI, ethanolic extract treated group V and hot aqueous extract treated group IV of Moringa oleifera as compared to group I. In delayed hypersensitivity test a significant increase (P< 0.05) in paw volume was observed in response to Sheep Red Blood Cells (SRBC's) in group II (hot aqueous extract), group III (ethanolic extract) and group VI (levamisole). Phagocytic index was also found to be non-significantly increased in levamisole treated group VI, ethanolic extract treated group III and hot aqueous extract treated group II as compared to group I. Thus the results showed that Moringa oleifera possess immunomodulatory property.